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Efficacy, Tolerability and Cost Effectiveness of Disease-Modifying Antirheumatic Drugs and Biologic Agents in Rheumatoid Arthritis.

COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention.

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Recently, to assess the level of cytokine expression during the course of CIA, CIA mice were sacrificed on a weekly basis starting at day 21, before the onset of clinical arthritis.

Sex hormones may play a role in RA, as evidenced by the disproportionate number of females with this disease, its amelioration during pregnancy, its recurrence in the early postpartum period, and its reduced incidence in women using oral contraceptives.

Arthritis patients know, as is true with their disease, catching problems early means less damage later.

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Current expert recommendation is to take 5 mg once a week, eg on a Friday (Monday for methotrexate, Friday for folic acid).

Etanercept (ETN) with methotrexate (MTX) is better than ETN monotherapy in patients with active rheumatoid arthritis despite MTX therapy: a randomized trial.

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In a more recent study the effects of MTX on COX-1 (thromboxane B 2) and COX-2 (PGE 2) activity were evaluated in whole blood of patients with RA treated with MTX.

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The available evidence does not support their current use in the management of RA.

Remove “TPA” and “TNK” from all standardized order sets, computerized provider order entry screens, and treatment protocols to avoid confusion.

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People responded to both treatments equally well, but conventional DMARDs are vastly cheaper than biologics and should be the first line of treatment in people with newly diagnosed rheumatoid arthritis.

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However, similar improvements in swollen joint counts assessed by the rheumatologist, physical functioning (for example, the HAQ score), and less erosive joint damage refute a nonspecific effect.

In the parallel approach, multiple DMARDs are simultaneously used from the outset.

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